In the present study the antioxidant effect of oral administration of ethanolic extract of eugenia jambolana seed kernel on tissue antioxidant enzymes and lipid peroxidation in liver and kidney of streptozotocininduced diabetic rats was evaluated. To validate scientifically a household remedy of eugenia jambolana seed based drug madhuhara churna ava trust regd in diabetes mellitus, a use based on ethnic preferences. The phytochemical analysis of the seeds of eugenia jambolana has revealed the presence of alkaloids, flavonoids, glycosides, phytosterols, saponins, tannins and triterpenoids 12. Witkamp, in comprehensive natural products ii, 2010. Photoelectrochemical solar cell using extract of eugenia jambolana. It is also anthelmintic and is good for sore throat, bronchitis, asthma, thirst, biliousness, dysentery, blood impurities and. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Antidiabetic effects of eugenia jambolana in the streptozotocininduced diabetic male albino rat kishalay jana, tushar kanti bera, debidas ghosh andrology, endocrinology and molecular medicine laboratory, biomedical laboratory science and management, vidyasagar university, midnapore, west bengal, india. Protective effect of eugenia jambolana seed kernel on. Phytochemical analyses and gastroprotective effects of eugenia.
The purple color of the ripe eugenia jambolana fruit is attributed to anthocyanins, a class of plant pigments that has attracted immense attention due to the potential health benefits of these compounds. Antiatherosclerotic potential of active principle isolated. Our previous studies revealed that a triterpenoidenriched jamun fruit extract tjfe showed beneficial effects on glucose homeostasis in nondiabetic mice. Potential antidiabetic mechanisms were investigated with blood glucose shortterm and longterm model, serum in. Lack of antidiabetic effect of a eugenia jambolana leaf decoction on. Preclinical evaluation of the antidiabetic effect of. A number of herbal formulas were tested, but ayush82 and d400 were most often studied. Preclinical evaluation of the antidiabetic effect of eugenia. Alopecia is a psychologically distressing condition. The lipid lowering effects of ethanolic extract of pulp of eugenia jambolana have already been demonstrated and they were found equal to simvastatin. Wo19970288a1 mixtures derived from grains of eugenia. Jambul eugenia jambolana jarnan jarnbu syzygium cumini java plum syzygium jambolana fruit pulp 8 seed powder.
A 6 month parallel designed open labeled randomized, controlled trial was conducted in 30 newly diagnosed type 2 diabetes mellitus. It is native to the indian subcontinent, adjoining regions of southeast asia, china and queensland. The present study evaluated the hypoglycemic activity of different parts of eugenia jambolana seeds such as whole seed, kernel, and seed coat on streptozotocininduced diabetic rats. Eugenia jambolana lam myrtaceae is used as ayurvedic plant for various medicinal purposes 1,2,5. Metabolite profiling in medicinally important plants is critical to resolve the problems associated with standardization and quality control. Brazilian journal of medical and biological research. Cytotoxic, trypanocidal, and antifungal activities of. Medicinal herbs used in indigenous medicines for the management of diabetes mellitus contain both organic and inorganic constituents. Androgenetic alopecia, which affects millions of men and women, is an androgendriven disorder. A taxonomic study of the genus eugenia myrtaceae in. Eugenia jambolana extract reduces the systemic exposure of. The flowers of this plant have been reported to possess contraceptive activity in male albino rats. Hypoglycemic and hypolipidemic effects of triterpenoid. Alternatives for replacing these drugs are natural extracts from eugenia jambolana, a plant used in traditional medicine because of its antimicrobial and biological activities.
New sesquiterpenoids from eugenia jambolana seeds and their. The aim of this study was to evaluate the antidiabetic activity of lh ii purified from ethanolic seed extract of eugenia jambolana in alloxaninduced mild diabetic md and severely diabetic sd rabbits. Metabolite fingerprinting of eugenia jambolana fruit pulp. Eugenia jambolana black plum, jamun is indigenous to india, thailand, and the philippines. Earlier studies of our laboratory have also shown the antiimplantation and antiestrogenic effect in female rats. The antioxidant effect of eugenia jambolana seed kernel was also compared with glibenclamide, a standard hypoglycemic drug. Eugenia jambolana or syzygium cumini, commonly known as jambul, jambolan, jamblang or jamun, is an evergreen tropical tree in the flowering plant family myrtaceae. Therefore, we used a combination of hplcuv, tandem lcms, and nmr.
Ameliorative effect of active principle isolated from seeds. Antidiabetic effect of a leaf extract from gymnema sylvestre in noninsulindependent diabetes mellitus patients. Antifertility activity of eugenia jambolana seed extract. Baskaran k, kizar ahamath b, radha shanmugasundaram k, shanmugasundaram er. Syzygium cumini, syzygium jambolanum, eugenia cumini. The present study was carried out to study the ameliorative effects of eugenia jambolana aqueous seeds extract 150 mgkg body wt. Antifertility activity of eugenia jambolana seed extract in. Syzygium cumini, commonly known as malabar plum, java plum, or black plum, is an evergreen tropical tree in the flowering plant family myrtaceae. Antidiabetic activity of eugenia jambolana seed kernels on.
Has 18 biological activities, 3 ethnobotanical uses. Ethanolic extract upon chromatographic purification yielded partially purified hypoglycemic principle siii which on further purification by sephadex lh 20 yielded pharmacological active. Antidiabetic activity of eugenia jambolana seed kernels. Ethanolic extract upon chromatographic purification yielded partially purified hypoglycemic principle siii which on further purification by sephadex lh 20 yielded pharmacological. Eugenia jambolana java plum is a tropical medicinal fruit rich in anthocyanins, however, its anticolon cancer properties are not well characterized. Directions take 5 gms half to one teaspoon 2 times a day jambul powder with water 1 hrs after meals. Eugenia jambolana java plum fruit extract exhibits anticancer activity against early stage human hct116 colon cancer cells and colon cancer stem cells by venkata charepalli 1, lavanya reddivari 2, ramakrishna vadde 1, suresh walia 3, sridhar radhakrishnan 1 and jairam k. Some of these inorganic trace elements possess antidiabetic properties, which accounts for the activity of medicinal herbs. Structure of anthocyanins from eugenia jambolana fruit liya.
There is disagreement in the literature on whether e. Syzygium jambos, eugenia jambos, jambosa jambos family. Most of the plant parts of eugenia jambolana are used in traditional system of. Cytotoxic, trypanocidal, and antifungal activities of eugenia. Administration of the ethanolic extract of kernel at a concentration of 100 mgkg of body weight significantly decreased the levels of blood glucose, blood urea, and cholesterol, increased glucose.
Lcms characterization, antikinetoplastide and cytotoxic activities of natural products from eugenia jambolana lam. Syzygium jambos, eugenia jambos, jambosa jambos, rose apple. Protective effect of eugenia jambolana seed kernel on tissue. A trypsin inhibitor was purified from the seeds of eugenia jambolana jambul with a fold purification of 14. Syzygium cumini, syzygium jambolanum, eugenia cumini, eugenia jambolana family. Thirtyfive of the studies included came from the western literature, 27 from the indian. The effects of eugenia jambolana, a household remedy for diabetes, were studied. Structure of anthocyanins from eugenia jambolana fruit.
Eugenia jambolana black plum, jamun is indigenous to india, thailand, and the. Lcms characterization, antikinetoplastide and cytotoxic. The present study reveals the efficacy of eugenia jambolana seed kernel in the amelioration of diabetes, which may be attributed to its hypoglycemic property along with its antioxidant potential. Fruit extract exhibits anticancer activity against early stage human hct116 colon cancer cells and colon cancer stem cells. Syzygium jambos, eugenia jambos, jambosa jambos, rose. Original article antihyperlipidaemic effects of eugenia. The present invention relates to mixtures which can be isolated from grains of eugenia jambolana lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament. Their structures were elucidated on the basis of nmr and ms spectrometry data analysis. It has been used for centuries in india to treat diabetes. Phenolics from eugenia jambolana seeds with advanced.
Hypoglycemic activity of inorganic constitutents in. Twenty four sesquiterpenoids, 124, including 11 new sesquiterpenoids, jambolanins ak, and two new norsesquiterpenoids, jambolanes a and b, along with six known triterpenoids, were isolated from the seeds of eugenia jambolana fruit. Therefore, we used a combination of hplcuv, tandem lcms, and nmr techniques to identify the structures of anthocyanins present in e. Rose apple is a popular fruit native to southeast asia.
A 6 month parallel designed open labeled randomized, controlled trial was conducted in 30 newly. Antiimplantation and antiestrogenic activity of ethyl. New sesquiterpenoids from eugenia jambolana seeds and. Distributed over africa, asia, australasia, northern america, pacific and southern america. This paper evaluates the use of eugenia jambolana seeds and fruit pulp for hair growth activity. The aqueous extract of dried seeds of eugenia jambolana eje is globally marketed as monotherapy. The name of the fruit is sometimes mistranslated as blackberry, which is a different fruit in an unrelated order. Phytochemistry, traditional uses and pharmacology of eugenia jambolana lam. Experiments were conducted in pots filled with gravel applied with treatment solutions containing nutrients and salts to produce salinity levels of eci5, 10, 15, 20 and 25 dsm1. Aug 25, 2004 the present study evaluated the hypoglycemic activity of different parts of eugenia jambolana seeds such as whole seed, kernel, and seed coat on streptozotocininduced diabetic rats. Eugenia jambolana in streptozotocininduced diabetic rats has recently been evaluated 11.
Oxidative stress plays an important role in chronic complications of diabetes. Hair growth activity of seeds and fruit pulp of eugenia. Antidiabetic potential of eugenia jambolana ethanolic seed. Pdf abstract jamun or indian black berry is obtained from eugenia jambolana synonymously known as syzygium cumini lam. A clinical trial of jambu eugenia jambolana in noninsulin dependant diabetes mellitus. According to ayurvedic scriptures, its bark is acrid, sweet, digestive and astringent to the bowels. Article information, pdf download for phytochemical analyses and. Pdf syzygium cumini commonly known as a jamun having promising.
Eugenia jambolana ej is an indian traditional herb widely used for the treatment of diabetes mellitus. This plant may be known by one or more common names in different places, and some are listed above. Notably, it is a referred, highly indexed, online international journal with high impact factor. Eugenia into the genera syzygium and eugenia sensu strictu. In the course of our investigation on the edible berry, eugenia jambolana known as jamun, 21 phenolics 121 were isolated and identified from its seeds. Myrtaceae rose apple, malabar plum, pomme rosa origin. Effect of eugenia jambolana on plasma glucose, insulin. This plant can be weedy or invasive according to the authoritative sources noted below. The said product is prepared from the pulp of the fruit eugenia jambolina comprising cleaning and drying the fruit to remove the extraneous material from the outer layer of the said fruit, deseeding the said fruit, soaking the deseeded pulp in water, mixing the said mixture of water and pulp and keeping it overnight in controlled cooled. Our previous studies revealed that a triterpenoidenriched jamun fruit extract tjfe showed beneficial effects on glucose homeostasis in nondiabetic. Eugenia jambolana, commonly known as jamun or indian blackberry, is an important source of bioactive compounds. Among its many colloquial names are java plum, portuguese plum, malabar plum, black plum, purple plum, and, in.
They showed reduction in serum total cholesterol, ldl cholesterol and hmgcoa reductase activity also with a significant fall in fasting blood glucose and glycosylated haemoglobin. The plant contains anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, and myricetin as its chief active constituents. Among these, one compound 1 is new and eleven compounds 3, 6, 9, 17, and 1921 are being reported from e. Us20010021401a1 process for the preparation of an herbal. Preclinical evaluation of the antidiabetic effect of eugenia jambolana seed powder in streptozotocindiabetic rats. These active cons isoquercetin, kaempferol tituents impart multiple pharmacological activities to the plant which includes antidiabetic, anticancer, antioxidant. Effect of root zone salinity on mineral nutrition and. Original article comparison of simvastatin with eugenia. Myrtaceae jambolan, java plum, jamun, naval, neredu, indian allspice. It creates groups of huge, darkcolored, berrylike fruits which are consumed raw, extracted as juice or even cooked. The present study was aimed to investigate the efficacy of seeds and pulp extracts of eugenia jambolana as a potential hair growth. International journal of science and research ijsr is published as a monthly journal with 12 issues per year.
The aim of this study was to analyze the inorganic trace elements present in eugenia jambolana seeds and to evaluate the. Administration of the ethanolic extract of kernel at a concentration of 100 mgkg of body weight significantly decreased the levels of blood glucose, blood urea. Eugenia jambolana jamun fruit has been reported to give. Most of the plant parts of eugenia jambolana are used in traditional system of medicine in india. Among the isolates, compound possessed a rare 6,7secoguaiene. Ameliorative effect of active principle isolated from. Diabetic rats were treated with this fraction at a dose of 200 mgkgd for 35 days. The aim of the present study was to investigate the antiatherosclerotic effect of active principle fiic isolated from aqueous fruit pulp extract of eugenia jambolana. All parts of the plant like stem bark, leaves, flower, fruit pulp and seeds are traditionally used for many diseases. Used as bee plant, human food, fuel, material and medicine. Lcms characterization, antikinetoplastide and cytotoxic activities of natural products from. This member of the myrtaceae is of wider interest for its medicinal applications than for its edible fruit. Eugenia jambolan is a large evergreen tropical tree. Streptozotocin diabetic female albino wistar rats weighing 150200 g n 6 were fed e.
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